About this book

This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.http://www.digibooks.cn/ebooks/

Table of contents

PART I: RESEARCH APPLICATIONS

1. The Many Faces of PNA
Peter E. Nielsen

2. Modulation of Nucleic Acid Information Processing by PNAs: Potential Use in Anti-Viral Therapeutics
Lionel Bastide, Bernard Lebleu and Ian Robbins

3. Targeted Gene Delivery: The Role of Peptide Nucleic Acid
Kenneth W. Liang, Feng Liu and Leaf Huang

4. Imaging Gene Expression in the Brain with Peptide Nucleic Acid (PNA) Antisense
Radiopharmaceuticals and Drug Targeting Technology
Ruben J. Boado and William M. Pardridge

5. Receptor-Specific Targeting with Complementary Peptide Nucleic Acids Conjugated
to Peptide Analogs and Radionuclides
Eric Wickstrom, Mathew L. Thakur and Edward R. Sauter

6. Morpholinos and PNAs Compared
James E. Summerton

7. Chemistry of Locked Nucleic Acids (LNA): Design, Synthesis and Bio

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