Molecular Pathogenesis of Cholestasis

Table of contents

I Basic Mechanisms

Physiology of bile formation James L Boyer

Hepatocellular transport systems

Basolateral membrane Peter J Meier-Abt
Canalicular membrane Michael Müller

Cell contacts

Tight junctions James M Anderson

Gap junctions in the liver W. Echevarria & M.H. Nathanson

Cholestasis: an intracellular "traffic jam" H. Kipp & I.M. Arias

The pathobiology of cholangiocytes G.LeSage et al. (G. Alpini)

Genetics, mutations and polymorphisms Laura Bull

Regulation of gene expression Saul J Karpen

Signal transduction in bile formation and cholestasis M Sawkat Anwer & C.R.L. Webster

Bile acid-mediated hepatocyte apoptosis in cholestasis G. J. Gores & H. Higuchi

Cholestasis and hepatic drug metabolism Hiroshi Suzuki

Pathology of cholestasis James M Crawford http://www.digibooks.cn/ebooks/

II Genetic Cholestatic Diseases

chapter deleted

Disorders of bile acid transport P.L.M. Jansen et al.

Genetic defects in lipid transport Ronald PJ Oude Elferink

Transport of bilirubin and ist conjugates across Y. Cui et al (D. Keppler)

hepatocellular mebrane domains and the conjugated

hyperbilirubinemia of Dubin-Johnson syndrome

Cystic Fibrosis Hugo R de Jonge

Copper transport Jonathan D Gitlin

Developmental defects (Alagille syndrome) Michelle Hadchouel (et al.)

III Acquired Cholestatic Diseases: Causes and Consequences

Primary Biliary Cirrhosis Margaret